Chapter 4 Functions of Myosin Motor Proteins in the Nervous System Daniel M. Suter Abstract The myosin superfamily consists of 24 classes of actin-based molecular motors that carry out a diverse array of cellular functions ranging from cell motility and morphology to cytokinesis, signal transduction, membrane trafficking, RNA and protein.

Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes

31-7-2017  · Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including hearing loss and vestibular dysfunction. Hearing is affected by both environmental and.

Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes

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1-4-1998  · Likewise, the mouse shaker-1 (sh1) mutation is caused by mutations in unconventional Myo7a (G ibson et al. 1995). Interestingly, homozygous sh1 mice have a phenotype that is nearly identical to that of homozygous sv mice. Three Myo7a mutations have been reported (G ibson et al. 1995), all being in the Myo7a head, the only

The European Society for Pigment Cell Research is a scientific society that was founded in 1985. It aims at the promotion of interdisciplinary knowledge and research on the pigmentary system, including both normal and pathological conditions. The Society provides the forum for interactive discussions by bringing together basic researchers and.

MYO7A encodes an unconventional myosin motor protein and is expressed in human embryonic RPE, photoreceptors, cochlear and vestibular neural epithelia (Weil et al., 1996). The shaker mouse (sh1) is a naturally occurring model with a spontaneous mutation in Myo7a…

25-7-2008  · A catechol-O-methyltransferase that is essential for auditory function in. Suspecting a mutation in the Myo7a locus, mutated in shaker-1 mice and in humans with Usher. we observed progressive degeneration of the organ of Corti. Though inner ear morphology appeared normal in homozygous add mice at P5, severe.

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Loss of Myo7A caused brush border defects and a reduction in the amount of the microvillus regulator Cad99C. We show that Myo7A and Cad99C form a molecular complex and that the cytoplasmic tail of Cad99C recruits Myo7A to microvilli. Our data indicate that Myo7A regulates the structure and spacing of microvilli, and interacts with Cad99C in vivo.

23-9-2013  · We have identified a novel mouse model of non-syndromic, sensorineural hearing loss via a comprehensive ENU (N-ethyl-N-nitrosourea) mouse screen at the Australian Phenomics Facility (APF). The hearing loss is congenital in these mice and affected progeny show abnormal structural morphology within the cochlear sensory regions.

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Although often overlooked, the mouse iris is also densely pigmented and easily observed, thus representing a similarly powerful opportunity for studying pigment cell biology. Here, we present an analysis of iris phenotypes among 16 mouse strains with mutations influencing melanosomes.

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Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes

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